Acid degradation of erythromycin A and erythromycin B
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چکیده
منابع مشابه
Preparation and evaluation of a new erythromycin derivative -- erythromycin taurate.
Erythromycin taurate, a new derivative of erythromycin, was prepared by reacting erythromycin base with tauric acid and its physico-chemical and biological properties were evaluated. The derivative has reasonably good solubility in organic solvents. The partition coefficient values in chloroform/water 1.17 and octanol/water 1.16 systems indicate its good distribution in various tissues in vivo....
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The acyltransferase (AT) domain in module 4 of the erythromycin polyketide synthase (PKS) was substituted with an AT domain from the rapamycin PKS module 2 in order to alter the substrate specificity from methylmalonyl-CoA to malonyl-CoA. The resulting strain produced 6-desmethyl erythromycin D as the predominant product. This AT domain swap completes the library of malonyl-CoA AT swaps on the ...
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ژورنال
عنوان ژورنال: Experientia
سال: 1971
ISSN: 0014-4754,1420-9071
DOI: 10.1007/bf02137246